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High‐flexion knee replacements have been developed to accommodate a large range of motion (RoM > 120°). Knee implants that allow for higher flexion may be more sensitive to femoral loosening as the knee load is relatively high during deep knee flexion, which could result in an increased failure potential at the implant–cement interface of the femoral component. A 3D finite element knee model was developed including a posterior‐stabilized high‐flexion knee replacement to analyze the stress state at the femoral implant–cement interface during a full squatting movement (RoM ≤ 155°). During deep flexion (RoM > 120°), tensile and shear stress concentrations were found at the implant–cement interface beneath the proximal part of the anterior flange. Particularly, the shear stresses at this interface location increased during high flexion, from a peak stress of 4.03 MPa at 90° to 6.89 MPa at 140° of …