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Recently, experiments were performed to determine the micromechanical behavior of the cement‐bone interface under tension‐compression loading conditions. These experiments were simulated using finite element analysis (FEA) to test whether the micromechanical response of the interface could be captured in micromodels. Models were created of experimental specimens based upon microcomputed tomography data, including the complex interdigitated bone‐cement morphology and simulated frictional contact at the interface. The models were subjected to a fully reversed tension‐compression load, mimicking the experimental protocol. Similar to what was found experimentally, the simulated interface was stiffer in compression than in tension, and the majority of displacement was localized to the cement‐bone interface. A weak correlation was found between the FEA‐predicted stiffness and the stiffness …