作者
David Birnie, Bernd Lemke, Kazutaka Aonuma, Henry Krum, Kathy Lai-Fun Lee, Maurizio Gasparini, Randall C Starling, Goran Milasinovic, John Gorcsan III, Mahmoud Houmsse, Athula Abeyratne, Alex Sambelashvili, David O Martin
发表日期
2013/9/1
期刊
Heart Rhythm
卷号
10
期号
9
页码范围
1368-1374
出版商
Elsevier
简介
Background
Acute studies have suggested that left ventricular pacing (LVP) may have benefits over biventricular pacing (BVP). The adaptive cardiac resynchronization therapy (aCRT) algorithm provides LVP synchronized to produce fusion with the intrinsic activation when the intrinsic atrioventricular (AV) interval is normal. The randomized double-blind adaptive cardiac resynchronization therapy trial demonstrated noninferiority of the aCRT algorithm compared to echocardiography-optimized BVP (control).
Objective
To examine whether synchronized LVP (sLVP) resulted in better clinical outcomes.
Methods
First, stratification by percent sLVP (%sLVP) and multivariate Cox proportional hazards model was used to assess the relationship between %sLVP and clinical outcomes. Second, outcomes were compared between patients in the aCRT arm (n = 318) and control patients (n = 160) stratified by intrinsic AV interval …
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D Birnie, B Lemke, K Aonuma, H Krum, KLF Lee… - Heart Rhythm, 2013