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The aim of the study was to examine factors that predict maternal stress, reported by mothers whose infants were diagnosed as having developmental disabilities at the beginning of participating in an early intervention programme ‘Me and My Mommy’ and after one year. A second goal was to identify and to portray a subgroup of resilient mothers. The sample consisted of 70 mothers from intact families, whose infants were diagnosed mostly with Down’s syndrome. All mothers were receiving early intervention services. The mothers were presented questionnaires—Sense of coherence (SOC); Family adaptability and cohesion evaluation (FACES III); Coping scale of parenting stress index (PSI‐SF), at the beginning and at the end of the year. They were also interviewed at the end of the intervention regarding their satisfaction with the programme. The results showed that at the beginning of the year, the mothers’ sense …