作者
Amy Loughman, SC Bowden, W D'souza
发表日期
2014/6/1
来源
Neuroscience & Biobehavioral Reviews
卷号
43
页码范围
20-34
出版商
Pergamon
简介
Cognitive function in idiopathic generalised epilepsies (IGE) is of increasing research attention. Current research seeks to understand phenotypic traits associated with this most common group of inherited epilepsies and evaluate educational and occupational trajectories. A specific deficit in executive function in a subgroup of IGE, juvenile myoclonic epilepsy (JME) has been a particular focus of recent research. This systematic review provides a quantitative synthesis of cognitive function outcomes in 26 peer-reviewed, case–control studies published since 1989. Univariate random-effects meta-analyses were conducted on seven cognitive factor-domains and separately on executive function. Patients with IGE demonstrated significantly lower scores on tests across all cognitive factor-domains except visual–spatial abilities. Effect sizes ranged from 0.42 to 0.88 pooled standard deviation units. The average reduction …
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