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Over the last decades, the growth in nanotechnology has provoked an increase in the number of its applications and consumer products that incorporate nanomaterials in their formulation. Metal nanoparticles are released to the marine environment and they can interact with cells by colloids forces establish a nano-bio interface. This interface can be compatible or generate bioadverse effects to cells. The daily use of CeO₂ nanoparticles (CeO₂ NPs) in industrial catalysis, sunscreen, fuel cells, fuel additives and biomedicine and their potential release into aquatic environments has turned them into a new emerging pollutant of concern. It is necessary to assess of effects of CeO₂ NPs in aquatic organisms and understand the potential mechanisms of action of CeO₂ NP toxicity to improve our knowledge about the intrinsic and extrinsic characteristic of CeO₂ NPs and the interaction of CeO₂ NPs with biomolecules in …