作者
Ryon M Bateman, MD Sharpe, JE Jagger, CG Ellis, J Solé-Violán, M López-Rodríguez, E Herrera-Ramos, J Ruíz-Hernández, L Borderías, J Horcajada, N González-Quevedo, O Rajas, M Briones, F Rodríguez de Castro, C Rodríguez Gallego, F Esen, G Orhun, P Ergin Ozcan, E Senturk, C Ugur Yilmaz, N Orhan, N Arican, M Kaya, M Kucukerden, M Giris, U Akcan, S Bilgic Gazioglu, E Tuzun, R Riff, O Naamani, A Douvdevani, R Takegawa, H Yoshida, T Hirose, N Yamamoto, H Hagiya, M Ojima, Y Akeda, O Tasaki, K Tomono, T Shimazu, S Ono, T Kubo, S Suda, T Ueno, T Ikeda, T Hirose, H Ogura, H Takahashi, M Ojima, J Kang, Y Nakamura, T Kojima, T Shimazu, T Ikeda, S Suda, Y Izutani, T Ueno, S Ono, T Taniguchi, M O, C Dinter, J Lotz, B Eilers, C Wissmann, R Lott, MM Meili, PS Schuetz, H Hawa, M Sharshir, M Aburageila, N Salahuddin, V Chantziara, S Georgiou, A Tsimogianni, P Alexandropoulos, A Vassi, F Lagiou, M Valta, G Micha, E Chinou, G Michaloudis, A Kodaira, T Ikeda, S Ono, T Ueno, S Suda, Y Izutani, H Imaizumi, MV De la Torre-Prados, A Garcia-De la Torre, A Enguix-Armada, A Puerto-Morlan, V Perez-Valero, A Garcia-Alcantara, N Bolton, J Dudziak, S Bonney, A Tridente, P Nee, G Nicolaes, M Wiewel, M Schultz, K Wildhagen, J Horn, R Schrijver, T Van der Poll, C Reutelingsperger, S Pillai, G Davies, G Mills, R Aubrey, K Morris, P Williams, P Evans, EG Gayat, J Struck, A Cariou, N Deye, B Guidet, S Jabert, J Launay, M Legrand, M Léone, M Resche-Rigon, E Vicaut, A Vieillard-Baron, A Mebazaa, R Arnold, M Capan, A Linder, P Akesson, M Popescu, D Tomescu, CL Sprung, R Calderon Morales, G Munteanu, E Orenbuch-Harroch, P Levin, H Kasdan, A Reiter, T Volker, Y Himmel, Y Cohen, J Meissonnier, L Girard, F Rebeaud, I Herrmann, B Delwarde, E Peronnet
发表日期
2016/4
期刊
Critical care
卷号
20
页码范围
13-182
出版商
BioMed Central
简介
Methods: Hypotensive sepsis was studied in male Sprague-Dawley rats using cecal ligation and perforation, with a 6-hour end point. Rat hindlimb skeletal muscle microcirculation was imaged using a dual wavelength spectrophotometric intravital microscopy system, and capillary RBC supply rate (SR= RBC/s), RBC SO2 and oxygen supply rate (qO2= pLO2/s) were quantified. Arterial NOx (nitrite+ nitrate) and RBC O2-dependent ATP efflux were measured using a nitric oxide (NO) analyzer and gas exchanger, respectively.
Results: Compared to control, sepsis increased capillary stopped flow and plasma lactate (p< 0.05). Increased plasma NOx (p< 0.001) was related to increased capillary RBC SR (p= 0.027). Analysis of 30-second capillary SR-SO2-qO2 profiles, revealed a shift towards decreased (p< 0.05) oxygen supply rates in some capillaries. Moreover, capillary response time within hypoxic capillaries (time to …
引用总数
20202021202220232024831464631