作者
Paula Ortiz-Sánchez, María Villalba-Orero, Marina M López-Olañeta, Javier Larrasa-Alonso, Fátima Sánchez-Cabo, Carlos Martí-Gómez, Emilio Camafeita, Jesús M Gómez-Salinero, Laura Ramos-Hernández, Peter J Nielsen, Jesús Vázquez, Michaela Müller-McNicoll, Pablo García-Pavía, Enrique Lara-Pezzi
发表日期
2019/7/5
期刊
Circulation research
卷号
125
期号
2
页码范围
170-183
出版商
Lippincott Williams & Wilkins
简介
Rationale:
RBPs (RNA binding proteins) play critical roles in the cell by regulating mRNA transport, splicing, editing, and stability. The RBP SRSF3 (serine/arginine-rich splicing factor 3) is essential for blastocyst formation and for proper liver development and function. However, its role in the heart has not been explored.
Objective:
To investigate the role of SRSF3 in cardiac function.
Methods and Results:
Cardiac SRSF3 expression was high at mid gestation and decreased during late embryonic development. Mice lacking SRSF3 in the embryonic heart showed impaired cardiomyocyte proliferation and died in utero. In the adult heart, SRSF3 expression was reduced after myocardial infarction, suggesting a possible role in cardiac homeostasis. To determine the role of this RBP in the adult heart, we used an inducible, cardiomyocyte-specific SRSF3 knockout mouse model. After SRSF3 depletion in cardiomyocytes …
学术搜索中的文章
P Ortiz-Sánchez, M Villalba-Orero, MM López-Olañeta… - Circulation research, 2019