作者
Thomas Lener, Mario Gimona, Ludwig Aigner, Verena Börger, Edit Buzas, Giovanni Camussi, Nathalie Chaput, Devasis Chatterjee, Felipe A Court, Hernando A del Portillo, Lorraine O'Driscoll, Stefano Fais, Juan M Falcon-Perez, Ursula Felderhoff-Mueser, Lorenzo Fraile, Yong Song Gho, André Görgens, Ramesh C Gupta, An Hendrix, Dirk M Hermann, Andrew F Hill, Fred Hochberg, Peter A Horn, Dominique de Kleijn, Lambros Kordelas, Boris W Kramer, Eva-Maria Krämer-Albers, Sandra Laner-Plamberger, Saara Laitinen, Tommaso Leonardi, Magdalena J Lorenowicz, Sai Kiang Lim, Jan Lötvall, Casey A Maguire, Antonio Marcilla, Irina Nazarenko, Takahiro Ochiya, Tushar Patel, Shona Pedersen, Gabriella Pocsfalvi, Stefano Pluchino, Peter Quesenberry, Ilona G Reischl, Francisco J Rivera, Ralf Sanzenbacher, Katharina Schallmoser, Ineke Slaper-Cortenbach, Dirk Strunk, Torsten Tonn, Pieter Vader, Bas WM van Balkom, Marca Wauben, Samir El Andaloussi, Clotilde Thery, Eva Rohde, Bernd Giebel
发表日期
2015/1/1
期刊
Journal of extracellular vesicles
卷号
4
期号
1
页码范围
30087
出版商
Taylor & Francis
简介
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types and participate in physiological and pathophysiological processes. EVs mediate intercellular communication as cell-derived extracellular signalling organelles that transmit specific information from their cell of origin to their target cells. As a result of these properties, EVs of defined cell types may serve as novel tools for various therapeutic approaches, including (a) anti-tumour therapy, (b) pathogen vaccination, (c) immune-modulatory and regenerative therapies and (d) drug delivery. The translation of EVs into clinical therapies requires the categorization of EV-based therapeutics in compliance with existing regulatory frameworks. As the classification defines subsequent requirements for manufacturing, quality control and clinical investigation, it is of major importance to define whether EVs are considered the active …
学术搜索中的文章
T Lener, M Gimona, L Aigner, V Börger, E Buzas… - Journal of extracellular vesicles, 2015
