作者
Nithin R Iyer, Thu-Thao Le, Michelle SL Kui, Hak-Chiaw Tang, Chee-Tang Chin, Soon-Kieng Phua, Jennifer A Bryant, Chee-Jian Pua, Briana Ang, Desiree-Faye Toh, Tar-Choon Aw, Chi-Hang Lee, Stuart A Cook, Martin Ugander, Calvin WL Chin
发表日期
2022/8
期刊
Hypertension
卷号
79
期号
8
页码范围
1804-1813
出版商
Lippincott Williams & Wilkins
简介
Background
The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear.
Methods
REMODEL (Response of the Myocardium to Hypertrophic Conditions in the Adult Population) is an observational cohort of asymptomatic patients with essential hypertension. All participants underwent cardiovascular magnetic resonance to assess for myocardial fibrosis: nonischemic late gadolinium enhancement (LGE), native myocardial T1, postcontrast myocardial T1, extracellular volume fraction including/excluding LGE regions, interstitial volume (extracellular volume×myocardial volume), and interstitial/myocyte ratio. Primary outcome was a composite of first occurrence acute coronary syndrome, heart failure hospitalization, strokes, and cardiovascular mortality. Patients were recruited from February 2016 and followed until June 2021.
Results
Of the 786 patients with …
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NR Iyer, TT Le, MSL Kui, HC Tang, CT Chin, SK Phua… - Hypertension, 2022