作者
Alison E Fohner, Dilrini K Ranatunga, Khanh K Thai, Brian L Lawson, Neil Risch, Akinyemi Oni-Orisan, Aline T Jelalian, Allan E Rettie, Vincent X Liu, Catherine A Schaefer
发表日期
2019/10/1
期刊
Pharmacogenetics and genomics
卷号
29
期号
8
页码范围
192-199
出版商
LWW
简介
Objective
To assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment.
Methods
A retrospective analysis of Resource on Genetic Epidemiology Research on Adult Health and Aging cohort participants who filled a phenytoin prescription between 1996 and 2017. We used laboratory test results, medication dispensing records, and medical notes to identify associations of CYP2C9 genotype with phenytoin blood concentration, neurologic side effects, and medication dispensing patterns reflecting clinician prescribing practice and patient response.
Results
Among 993 participants, we identified 69% extensive, 20% high-intermediate, 10% low-intermediate, and 2% poor metabolizers based on CYP2C9 genotypes. Compared with extensive metabolizer genotype, low-intermediate/poor metabolizer genotype was associated with …
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AE Fohner, DK Ranatunga, KK Thai, BL Lawson… - Pharmacogenetics and genomics, 2019