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OBJECTIVE:

Decreased local availability of nitric oxide (NO) may mediate chronic vasospasm after aneurysmal subarachnoid hemorrhage (SAH). Previous reports have shown that early treatment with NO prevents vasospasm in animals. We evaluated the efficacy of controlled-release polymers that contain the NO donor diethylenetriamine (DETA-NO) for the delayed treatment of vasospasm in a rabbit model of SAH.

METHODS:

DETA-NO 20%(wt/wt) was incorporated into ethylene-vinyl acetate (EVAc) polymers. Animals (n= 52) were randomized to two experimental groups. In the first group (n= 32), animals received SAH and implantation of either 20% DETA-NO/EVAc polymer at a dose of 0.5 mg/kg of DETA-NO (n= 16) or empty EVAc polymer (n= 16). Polymers were implanted 24 (n= 16) or 48 hours (n= 16) after SAH. In the second group (n= 20), animals received SAH and implantation of either 20% DETA-NO …