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In image fusion literature, multi-scale transform (MST) and sparse representation (SR) are two most widely used signal/image representation theories. This paper presents a general image fusion framework by combining MST and SR to simultaneously overcome the inherent defects of both the MST- and SR-based fusion methods. In our fusion framework, the MST is firstly performed on each of the pre-registered source images to obtain their low-pass and high-pass coefficients. Then, the low-pass bands are merged with a SR-based fusion approach while the high-pass bands are fused using the absolute values of coefficients as activity level measurement. The fused image is finally obtained by performing the inverse MST on the merged coefficients. The advantages of the proposed fusion framework over individual MST- or SR-based method are first exhibited in detail from a theoretical point of view, and then …