作者
Wen-Hung Chung, Wan-Chun Chang, Sophie L Stocker, Chiun-Gung Juo, Garry G Graham, Ming-Han H Lee, Kenneth M Williams, Ya-Chung Tian, Kuo-Chang Juan, Yeong-Jian Jan Wu, Chih-Hsun Yang, Chee-Jen Chang, Yu-Jr Lin, Richard O Day, Shuen-Iu Hung
发表日期
2015/12/1
期刊
Annals of the rheumatic diseases
卷号
74
期号
12
页码范围
2157-2164
出版商
BMJ Publishing Group Ltd
简介
Objective
Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-threatening severe cutaneous adverse reactions (SCAR), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS) and toxic epidermal necrosis (TEN). The prognostic factors for allopurinol-related SCAR remain unclear. This study aimed to investigate the relationship of dosing, renal function, plasma levels of oxypurinol and granulysin (a cytotoxic protein of SJS/TEN), the disease severity and mortality in allopurinol-SCAR.
Methods
We prospectively enrolled 48 patients with allopurinol-SCAR (26 SJS/TEN and 22 DRESS) and 138 allopurinol-tolerant controls from 2007 to 2012. The human leucocyte antigen (HLA)-B*58:01 status, plasma concentrations of oxypurinol and granulysin were determined.
Results
In this cohort, HLA-B*58:01 was strongly associated with allopurinol …
学术搜索中的文章
WH Chung, WC Chang, SL Stocker, CG Juo… - Annals of the rheumatic diseases, 2015