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Aim:

To compare the efficacy of oral lycopene and injection betamethasone with control group in the management of oral submucous fibrosis.

Materials and Methods:

A hospital based longitudinal study, conducted on 270 patients over a period of 2 years (September 2010-September 2012).

Results:

Out of 270 cases 223 (82.59%) were males and 47 (17.40%) were females which showed a male predominance and the ratio was 5: 1. In stage I it was found that both the test groups, ie, injection betamethasone and capsule lycopene had a significant improvement in mouth opening than control group. In stage II, it was found that the test group injection betamethasone showed 24 better results as compared to capsule lycopene this could be because of better accessibility of the fibrotic bands for injecting betamethasone solution at the site of the lesion and showed highly significant difference (P< 0.0001). In stage III, it was …