作者
Augustinus PT van der Ploeg, Alexander CJ van Akkooi, Piotr Rutkowski, Zbigniew I Nowecki, Wanda Michej, Angana Mitra, Julia A Newton-Bishop, Martin Cook, Iris MC van der Ploeg, Omgo E Nieweg, Mari FCM van den Hout, Paul AM van Leeuwen, Christiane A Voit, Francesco Cataldo, Alessandro Testori, Caroline Robert, Harald J Hoekstra, Cornelis Verhoef, Alain Spatz, Alexander MM Eggermont
发表日期
2011/6/1
期刊
Journal of clinical oncology
卷号
29
期号
16
页码范围
2206-2214
出版商
American Society of Clinical Oncology
简介
Purpose
Prognosis in patients with sentinel node (SN) –positive melanoma correlates with several characteristics of the metastases in the SN such as size and site. These factors reflect biologic behavior and may separate out patients who may or may not need additional locoregional and/or systemic therapy.
Patients and Methods
Between 1993 and 2008, 1,080 patients (509 women and 571 men) were diagnosed with tumor burden in the SN in nine European Organisation for Research and Treatment of Cancer (EORTC) melanoma group centers. In total, 1,009 patients (93%) underwent completion lymph node dissection (CLND). Median Breslow thickness was 3.00 mm. The median follow-up time was 37 months. Tumor load and tumor site were reclassified in all nodes by the Rotterdam criteria for size and in 88% by the Dewar criteria for topography.
Results
Patients with submicrometastases (< 0.1 mm in …
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APT van der Ploeg, ACJ van Akkooi, P Rutkowski… - Journal of clinical oncology, 2011