作者
K Brookes, Xiaohui Xu, Wai Chen, Kaixin Zhou, B Neale, N Lowe, R Aneey, Barbara Franke, Michael Gill, Richard Ebstein, J Buitelaar, P Sham, Desmond Campbell, James Knight, Penny Andreou, Mareike Altink, Renée Arnold, Frits Boer, Cathelijne Buschgens, Louise Butler, Hanna Christiansen, Liat Feldman, Karin Fleischman, Ellen Fliers, Raoul Howe-Forbes, Abigail Goldfarb, Alexander Heise, Isabel Gabriëls, Isabelle Korn-Lubetzki, Rafeala Marco, She'era Medad, Ruud Minderaa, Fernando Mulas, U Müller, Aisling Mulligan, Karina Rabin, N Rommelse, Vaheshta Sethna, Jean Sorohan, Henrik Uebel, Lamprini Psychogiou, Anne Weeks, R Barrett, I Craig, Tobias Banaschewski, E Sonuga-Barke, Jacques Eisenberg, Jonna Kuntsi, Iris Manor, Peter McGuffin, Ana Miranda, Robert D Oades, Robert Plomin, Herbert Roeyers, Aribert Rothenberger, J Sergeant, Hans-Christoph Steinhausen, E Taylor, Margaret Thompson, Stephen V Faraone, Philip Asherson, Lena Johansson
发表日期
2006/10
期刊
Molecular psychiatry
卷号
11
期号
10
页码范围
934-953
出版商
Nature Publishing Group
简介
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or …
引用总数
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K Brookes, X Xu, W Chen, K Zhou, B Neale, N Lowe… - Molecular psychiatry, 2006