作者
Thomas M Kessler, Hansjörg Danuser, Martin Schumacher, Urs E Studer, Fiona C Burkhard
发表日期
2005/5
期刊
Neurourology and Urodynamics: Official Journal of the International Continence Society
卷号
24
期号
3
页码范围
231-236
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Aims
To assess and compare the effect of botulinum A toxin (BTX‐A) injections into the detrusor in idiopathic and neurogenic detrusor overactivity resistant to anticholinergic treatment.
Patients and Methods
In a prospective study, 11 patients with idiopathic and 11 with neurogenic detrusor overactivity resistant to anticholinergic treatment were injected with 300 U of BTX‐A (Botox®) into the detrusor. Clinical and urodynamic parameters were assessed before and after BTX‐A injections.
Results
In idiopathic as well as in neurogenic detrusor overactivity, median daytime frequency decreased significantly from 11 to 4 (P = 0.004) and 12 to 5 (P = 0.001), median nocturia from 3 to 1 (P = 0.004) and 3 to 1 (P = 0.001), and median number of used pads from 5 to 0 (P = 0.001) and 5 to 0 (P = 0.002), respectively. There was a significant increase in median maximum cystometric capacity from 220 to 340 ml (P …
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