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Drugs incorporated into hair are exposed to the environment, and cosmetic and chemical treatments, with possible decreases in their content. Knowledge concerning the effect of sunlight on drug content in hair can be helpful to forensic toxicologists, in particular, when investigating drug concentrations above or below pre-determined cut-offs. Twenty-eight authentic positive hair samples were selected which had previously tested positive for ethyl glucuronide (EtG). Washed hair were divided into two identical tufts, with the former exposed at 13,219 J/cm² (300–800 nm spectrum of irradiance) for 48 h in a solar simulator, and the latter kept in the dark. Hair samples were extracted and analyzed by ultra performance liquid chromatography–tandem mass spectrometry. The percentage of photodegradation was calculated for EtG. In parallel, photodegradation processes of standard molecule dissolved in aqueous …