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Clinical transplantation medicine currently faces a significant shortage of organ donors to supply the need of an increasingly aged population. Despite this, organs are still discarded due to graft stress induced by hypoxia or ischemia prior to procurement. Approaches to minimize donor organ discard include appropriate organ preservation and monitoring of organ function. Predominant organ preservation strategies involve hypothermia between 0 C and 12 C. In this study, we investigate the effect of temperature alone on tissue microstructural and biochemical parameters during cold preservation of mouse organs. To the best of our knowledge, this is the first study evaluating this cooling effect on multiple tissue parameters such as blood oxygenation, concentrations of blood, methemoglobin, water, lipid, and bile as well as scattering amplitude, Mie scattering power and fraction of Rayleigh scattering. These …