作者
Omar Hyder, Hugo Marques, Carlo Pulitano, J Wallis Marsh, Sorin Alexandrescu, Todd W Bauer, T Clark Gamblin, Georgios C Sotiropoulos, Andreas Paul, Eduardo Barroso, Bryan M Clary, Luca Aldrighetti, Cristina R Ferrone, Andrew X Zhu, Irinel Popescu, Jean-Francois Gigot, Gilles Mentha, Shen Feng, Timothy M Pawlik
发表日期
2014/5/1
期刊
JAMA surgery
卷号
149
期号
5
页码范围
432-438
出版商
American Medical Association
简介
Importance
Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the liver that is increasing in incidence, and the prognostic factors associated with outcome after surgery remain poorly defined.
Objective
To combine clinicopathologic variables associated with overall survival after resection of ICC into a prediction nomogram.
Design, Setting, and Participants
We performed an international multicenter study of 514 patients who underwent resection for ICC at 13 major hepatobiliary centers in the United States, Europe, and Asia from May 1, 1990, through December 31, 2011. Multivariate Cox proportional hazards regression modeling with backward selection using the Akaike information criteria was used to select variables for construction of the nomogram. Discrimination and calibration were performed using Kaplan-Meier curves and calibration plots.
Interventions
Surgical resection of ICC at a participating …
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