作者
Mechteld C De Jong, Hari Nathan, Georgios C Sotiropoulos, Andreas Paul, Sorin Alexandrescu, Hugo Marques, Carlo Pulitano, Eduardo Barroso, Bryan M Clary, Luca Aldrighetti, Cristina R Ferrone, Andrew X Zhu, Todd W Bauer, Dustin M Walters, T Clark Gamblin, Kevin T Nguyen, Ryan Turley, Irinel Popescu, Catherine Hubert, Stephanie Meyer, Richard D Schulick, Michael A Choti, Jean-Francois Gigot, Gilles Mentha, Timothy M Pawlik
发表日期
2011/8/10
期刊
Journal of Clinical Oncology
卷号
29
期号
23
页码范围
3140-3145
出版商
American Society of Clinical Oncology
简介
Purpose
To identify factors associated with outcome after surgical management of intrahepatic cholangiocarcinoma (ICC) and examine the impact of lymph node (LN) assessment on survival.
Patients and Methods
From an international multi-institutional database, 449 patients who underwent surgery for ICC between 1973 and 2010 were identified. Clinical and pathologic data were evaluated using uni- and multivariate analyses.
Results
Median tumor size was 6.5 cm. Most patients had a solitary tumor (73%) and no vascular invasion (69%). Median survival was 27 months, and 5-year survival was 31%. Factors associated with adverse prognosis included positive margin status (hazard ratio [HR], 2.20; P < .001), multiple lesions (HR, 1.80; P = .001), and vascular invasion (HR, 1.59; P = .015). Tumor size was not a prognostic factor (HR, 1.03; P = .23). Patients were stratified using the American Joint Committee on …
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MC De Jong, H Nathan, GC Sotiropoulos, A Paul… - Journal of Clinical Oncology, 2011