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Arterial stiffness is a major biomarker of cardiovascular health and a key predictor of cardiovascular events. 1 In the clinical setting, pulse wave velocity (PWV) is used as a noninvasive surrogate for arterial stiffness. Local PWV represents the stiffness of a small segment of a given vessel. This is an important assessment for monitoring the progression of local and heterogenous disease such as atherosclerosis, connective tissue disorders, and the iatrogenic impacts of radiation. Currently, the most common tool for measuring local PWV is the theoretical Bramwell-Hill (BH) equation. 2 To make it clinically applicable, this equation only requires the measurement of blood pressure and vessel diameter at systolic and diastolic points (see equation 1). Due to the limitations of the BH equation, other techniques are being researched so that accurate local stiffness assessments can be used clinically. 3