作者
Slaven Crnkovic, Bakytbek Egemnazarov, Rachel Damico, Leigh M Marsh, Bence M Nagy, Philipp Douschan, Kwame Atsina, Todd M Kolb, Stephen C Mathai, Jody E Hooper, Bahil Ghanim, Walter Klepetko, Friedrich Fruhwald, Dirk Lassner, Andrea Olschewski, Horst Olschewski, Paul M Hassoun, Grazyna Kwapiszewska
发表日期
2019/6/15
期刊
American journal of respiratory and critical care medicine
卷号
199
期号
12
页码范围
1550-1560
出版商
American Thoracic Society
简介
Rationale: Remodeling and fibrosis of the right ventricle (RV) may cause RV dysfunction and poor survival in patients with pulmonary hypertension.
Objectives: To investigate the consequences of RV fibrosis modulation and the accompanying cellular changes on RV function.
Methods: Expression of fibrotic markers was assessed in the RV of patients with pulmonary hypertension, the murine pulmonary artery banding, and rat monocrotaline and Sugen5416/hypoxia models. Invasive hemodynamic and echocardiographic assessment was performed on galectin-3 knockout or inhibitor-treated mice.
Measurements and Main Results: Established fibrosis was characterized by marked expression of galectin-3 and an enhanced number of proliferating RV fibroblasts. Galectin-3 genetic and pharmacologic inhibition or antifibrotic treatment with pirfenidone significantly diminished RV fibrosis progression in the pulmonary …
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S Crnkovic, B Egemnazarov, R Damico, LM Marsh… - American journal of respiratory and critical care …, 2019