作者
Aleksandra Zeljkovic, Vesna Spasojevic-Kalimanovska, Jelena Vekic, Zorana Jelic-Ivanovic, Aleksandra Topic, Natasa Bogavac-Stanojevic, Slavica Spasic, Ana Vujovic, Dimitra Kalimanovska-Ostric
发表日期
2008/6
期刊
Clinical and experimental medicine
卷号
8
页码范围
109-116
出版商
Springer Milan
简介
Background
Alterations in plasma lipoprotein subclass distribution affect the risk for coronary artery disease (CAD). However, it is unclear whether the determination of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) phenotypes may or may not improve the ability to predict CAD development.
Methods
Polyacrylamide gradient (3–31%) gel electrophoresis was used to simultaneously determine size and distribution of lipoprotein subclasses in 181 CAD patients and 178 controls.
Results
Mean LDL and HDL subclass sizes were significantly smaller in patients than in controls (p < 0.001). Multivariate logistic regression analysis showed that small dense LDL particles were independent CAD risk predictors (OR = 2.867, p < 0.01), even when adjusted for other traditional risk factors, while small HDL particles …
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A Zeljkovic, V Spasojevic-Kalimanovska, J Vekic… - Clinical and experimental medicine, 2008