作者
Zorana Milanović, Jelena Vekić, Vladimir Radonjić, Anja Ilić Božović, Aleksandra Zeljković, Jelena Janac, Vesna Spasojević‐Kalimanovska, Jesse Buch, Ramaswamy Chandrashekar, Žanka Bojić‐Trbojević, Ljiljana Hajduković, Mary M Christopher, Milica Kovačević Filipović
发表日期
2019/7
期刊
Journal of veterinary internal medicine
卷号
33
期号
4
页码范围
1686-1694
出版商
John Wiley & Sons, Inc.
简介
Background
Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis.
Hypothesis
Dogs with B. canis‐induced APR develop dyslipidemia with altered lipoprotein concentration and morphology.
Animals
Twenty‐nine client‐owned dogs with acute B. canis infection and 10 clinically healthy control dogs.
Methods
Observational cross‐sectional study. Serum amyloid A (SAA) was measured using ELISA. Cholesterol, phospholipids, and triglycerides were determined biochemically. Lipoproteins were separated using agarose gel electrophoresis. Lipoprotein diameter was assessed by polyacrylamide gradient gel electrophoresis; correlation with ApoA‐1 (radioimmunoassay) and SAA was determined.
Results
Dogs with B. canis infection had a marked APR (median SAA, 168.3 μg/mL; range, 98.1‐716.2 …
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Z Milanović, J Vekić, V Radonjić, A Ilić Božović… - Journal of veterinary internal medicine, 2019