作者
Sina Sharifi, Mohammad Mirazul Islam, Hannah Sharifi, Rakibul Islam, Darrell Koza, Felisa Reyes-Ortega, David Alba-Molina, Per H Nilsson, Claes H Dohlman, Tom Eirik Mollnes, James Chodosh, Miguel Gonzalez-Andrades
发表日期
2021/11/1
期刊
Bioactive materials
卷号
6
期号
11
页码范围
3947-3961
出版商
Elsevier
简介
Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor, utilizing epoxide ring-opening reactions and visible light-crosslinking. This chemical modification allows the obtaining of an elastic protein-based hydrogel (GELGYM) with excellent biomimetic properties, approaching those of the native tissue. GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80 …
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