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This work addresses economic and process aspects of the supercritical fluid extraction (SFE) of Eucalyptus globulus bark at industrial scale. Broken plus intact cells (BIC) model was applied to existing data and new SFE curves were simulated. Then, statistical optimization was performed with Response Surface Methodology (RSM) involving of 5 factors (pressure, temperature, cosolvent content, solvent flow rate and extraction time), and four responses: Total Yield (η Total), Productivity, Cost of Manufacturing (COM) and Process Energy. The design and simulation of the industrial process (Aspen Plus® software) was performed including the employment of cosolvent in the system. The best COM scored 28.1€ k g e x t r a c t-1, where η Total was 0.84-0.96 wt.%, Productivity reached 311–362 ton extract year-1, and Process Energy scored 1.46–2.10 GJ kg extract-1. These results underline that SFE provides an …