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Eucalyptus globulus bark is an interesting source of triterpenic acids (TTAs), mainly ursolic, betulinic, oleanolic, betulonic, 3-acetylursolic, and 3-acetyloleanolic acids, which possess confirmed bioactivity. In this work, the supercritical fluid extraction of E. globulus bark has been carried out in order to measure the cumulative curves in terms of total yield, TTAs yield, free TTAs yield, acetylated TTAs yield, and TTAs concentration in the extracts. The influence of pressure, temperature, ethanol (cosolvent) content, and carbon dioxide flow rate upon the previous responses have been analyzed by performing experiments in the ranges of 120–200bar, 40–60°C, 0–5% EtOH, and [Formula: see text] . The experimental curves have been modeled with Logistic, Desorption, Simple Single Plate, and Diffusion models. In the whole, results showed that pressure and ethanol content imparted a significant effect upon extraction …