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Lycopene is an important carotenoid present in the large volumes of tomato residues generated annually. Its SFE was studied here with two main objectives: optimization of operating conditions and selection of supercritical solvent (CO 2 versus ethane). Accordingly, a hybrid approach using the response surface methodology and cost of manufacturing (COM) concept was implemented to establish the best conditions independently of the type of extraction curves available. This approach provides accurate results even in the absence of well-defined periods of extraction (ie, constant extraction rate branch and the maximum plateau). The minimum COM was 1.8 k€ k g lycopene− 1 for CO 2 at 500 bar/90° C/25 kg CO 2 k g sample− 1. At 300 bar/60° C the supercritical ethane achieved better results due to the higher extraction rates observed, which originated shorter extraction cycles and thus greater annual …