作者
Shoaib Manzoor, Daniyah A Almarghalani, Antonisamy William James, Md Kausar Raza, Tasneem Kausar, Shahid M Nayeem, Nasimul Hoda, Zahoor A Shah
发表日期
2023/1
期刊
Pharmaceutical research
卷号
40
期号
1
页码范围
167-185
出版商
Springer US
简介
Objective
Neuroprotection is a precise target for the treatment of neurodegenerative diseases, ischemic stroke, and traumatic brain injury. Pyrimidine and its derivatives have been proven to use antiviral, anticancer, antioxidant, and antimicrobial activity prompting us to study the neuroprotection and anti-inflammatory activity of the triazole-pyrimidine hybrid on human microglia and neuronal cell model.
Methods
A series of novel triazole-pyrimidine-based compounds were designed, synthesized and characterized by mass spectra, 1HNMR, 13CNMR, and a single X-Ray diffraction analysis. Further, the neuroprotective, anti-neuroinflammatory activity was evaluated by cell viability assay (MTT), Elisa, qRT-PCR, western blotting, and molecular docking.
Results
The molecular results revealed that triazole-pyrimidine hybrid compounds have promising neuroprotective and anti-inflammatory properties. Among the 14 …
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