作者
Lisa Staadegaard, Minttu M Rönn, Nirali Soni, Meghan E Bellerose, Paul Bloem, Marc Brisson, Mathieu Maheu-Giroux, Ruanne V Barnabas, Melanie Drolet, Philippe Mayaud, Shona Dalal, Marie-Claude Boily
发表日期
2022/10/1
来源
EClinicalMedicine
卷号
52
出版商
Elsevier
简介
Background
Vaccines have been demonstrated to protect against high-risk human papillomavirus infection (HPV), including HPV-16/18, and cervical lesions among HIV negative women. However, their efficacy remains uncertain for people living with HIV (PLHIV).We systematically reviewed available evidence on HPV vaccine on immunological, virological, or other biological outcomes in PLHIV.
Methods
We searched five electronic databases (PubMed, Medline and Embase, clinicaltrials.gov and the WHO clinical trial database) for longitudinal prospective studies reporting immunogenicity, virological, cytological, histological, clinical or safety endpoints following prophylactic HPV vaccination among PLHIV. We included studies published by February 11th, 2021. We summarized results, assessed study quality, and conducted meta-analysis and subgroup analyses, where possible.
Findings
We identified 43 …
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