作者
K Liang Zeng, Sten Myrehaug, Hany Soliman, Zain A Husain, Chia-Lin Tseng, Jay Detsky, Mark Ruschin, Eshetu G Atenafu, Christopher D Witiw, Jeremie Larouche, Leodante da Costa, Pejman Jabehdar Maralani, Wendy R Parulekar, Arjun Sahgal
发表日期
2022/10/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
114
期号
2
页码范围
293-300
出版商
Elsevier
简介
Purpose
Stereotactic body radiation therapy (SBRT) improves complete pain response for painful spinal metastases compared with conventional external beam radiation therapy (cEBRT). We report mature local control and reirradiation rates in a large cohort of patients treated with SBRT versus cEBRT enrolled previously in the Canadian Clinical Trials Group Symptom Control 24 phase 2/3 trial.
Methods and Materials
One hundred thirty-seven of 229 (60%) patients randomized to 24 Gy in 2 SBRT fractions or 20 Gy in 5 cEBRT fractions were retrospectively reviewed. By including all treated spinal segments, we report on 66 patients (119 spine segments) treated with SBRT and 71 patients (169 segments) treated with cEBRT. The primary outcomes were magnetic resonance–based local control and reirradiation rates for each treated spine segment.
Results
The median follow-up was 11.3 months (interquartile range, 5 …
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KL Zeng, S Myrehaug, H Soliman, ZA Husain… - International Journal of Radiation Oncology* Biology …, 2022