作者
James Stewart, Arjun Sahgal, Young Lee, Hany Soliman, Chia-Lin Tseng, Jay Detsky, Zain Husain, Ling Ho, Sunit Das, Pejman Jabehdar Maralani, Nir Lipsman, Greg Stanisz, James Perry, Hanbo Chen, Eshetu G Atenafu, Mikki Campbell, Angus Z Lau, Mark Ruschin, Sten Myrehaug
发表日期
2021/3/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
109
期号
3
页码范围
736-746
出版商
Elsevier
简介
Purpose
Magnetic resonance image (MRI) guided radiation therapy has the potential to improve outcomes for glioblastoma by adapting to tumor changes during radiation therapy. This study quantifies interfraction dynamics (tumor size, position, and geometry) based on sequential magnetic resonance imaging scans obtained during standard 6-week chemoradiation.
Methods and Materials
Sixty-one patients were prospectively imaged with gadolinium-enhanced T1 (T1c) and T2/FLAIR axial sequences at planning (Fx0), fraction 10 (Fx10), fraction 20 (Fx20), and 1 month after the final fraction of chemoradiation therapy (P1M). Gross tumor volumes (GTVs) and clinical target volumes (CTVs) were contoured at all time points. Target dynamics were quantified by absolute volume (V), volume relative to Fx0 (Vrel), and the migration distance (dmigrate; the linear displacement of the GTV or CTV relative to Fx0). Temporal …
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J Stewart, A Sahgal, Y Lee, H Soliman, CL Tseng… - International Journal of Radiation Oncology* Biology …, 2021