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Recent studies point to work-related stress as an increasing problem for knowledge workers. However, the working life in knowledge-intensive companies is often described as good and stimulating. The aim of this study is to explore the organizational options for preventing work-related problems in knowledge work. This calls for a study of the characteristics of knowledge work, stress management interventions and an in-depth analysis of the organizational factors causing frustrations and work-related problems in relation to knowledge work. In a qualitative study, 27 respondents were interviewed. They represented different stakeholders in five Danish knowledge-intensive companies, which comprised two consultancies and three engineering consulting companies. The study shows that knowledge work comprises a paradox, since the same work-related or organizational issues could be experienced as both an …