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Objective: To investigate the effectiveness of an educational Quality Use of Medicines program, delivered at the level of general practice, on medicines use, falls and quality of life in people aged ≥ 65 years.

Design: Cluster randomised controlled trial conducted in 2002.

Setting: General practices in the Hunter Region, New South Wales, Australia.

Participants: Twenty general practitioners recruited 849 patients to participate in the study.

Intervention: Education (academic detailing, provision of prescribing information and feedback); medication risk assessment; facilitation of medication review; financial incentives.

Main outcome measures: Primary measures: a composite score reflecting use of benzodiazepines, non‐steroidal anti‐inflammatory drugs (NSAIDs) and thiazide diuretics; secondary measures: use of medication reviews, occurrence of falls, quality of life (as assessed by SF‐12 and EQ‐5D survey scores …