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Objective  To describe the prevalence of risk factors for medication misadventures among older people in general practice.

Design  Descriptive cross‐sectional analysis.

Setting  General practices, New South Wales, Australia.

Participants  Twenty general practitioners in 16 practices recruited 849 practice attendees aged 65 years and over.

Outcome measure  Risk factors for medication misadventures.

Results  Almost all participants (95%) had used at least one medication for more than 6 months. More than half of the participants had more than one doctor involved in their care (59%), had three or more health conditions (57%), or used five or more medicines (54%). With regard to potential adverse drug reactions, in the last month 39% of participants experienced difficulties sleeping, one‐third felt drowsy or dizzy (34%), and about a quarter had a skin rash (28%), leaked urine (27%), had stomach problems …