作者
ZA Zakaria, MS Rofiee, MN Somchit, A Zuraini, MR Sulaiman, LK Teh, MZ Salleh, K Long
发表日期
2011
期刊
Evidence‐Based Complementary and Alternative Medicine
卷号
2011
期号
1
页码范围
142739
出版商
Hindawi Publishing Corporation
简介
The present study aims to determine the hepatoprotective effect of MARDI‐produced virgin coconut oils, prepared by dried‐ or fermented‐processed methods, using the paracetamol‐induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in‐depth study.
学术搜索中的文章
ZA Zakaria, MS Rofiee, MN Somchit, A Zuraini… - Evidence‐Based Complementary and Alternative …, 2011