作者
Fernando Albericio, Hendrik G Kruger
发表日期
2012/8
期刊
Future medicinal chemistry
卷号
4
期号
12
页码范围
1527-1531
出版商
Future Science Ltd
简介
The analysis of these peptides by therapeutic categories is an indication of the versatility of peptides to tackle a large number of biochemical transgressions. Thus, boceprevir and telaprevir are antiviral therapeutics used for the treatment of hepatitis C; ecallantide and icatibant are cardiovascular agents; romidepsin and brentuximab vedotin are anticancer drugs; telavancin is an antibacterial; and liraglutide is used in metabolism for the treatment of Type 2 diabetes. The expansion of the therapeutic applications of peptides is more visible when drugs in clinical and preclinical phases are analyzed. At present, in addition to almost 80 peptides on the market, approximately 200 more are in clinical phases and 400 in advanced preclinical stages [11, 12]. Metabolism is currently the largest thera peutic field (25%) for peptides, followed by cancer (16%). This distribution marks an important change in trend, because towards …
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学术搜索中的文章
F Albericio, HG Kruger - Future medicinal chemistry, 2012