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Castration-resistant (CR) prostate cancer (PCa) treatment options are limited. A substantial sub-population of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) activation, inhibiting androgen biosynthesis could be an effective treatment option for these patients. Study Objective: The androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole were found to directly inhibit growth, migration, and colony formation of androgen-independent LNCaP C-81 cells that exhibit de novo androgen biosynthesis, with simvastatin being the most effective. Importantly, statins specifically enhanced growth suppression in combination with anti-androgen abiraterone acetate effects on CR PCa cells. Conclusion: Statins can be combined with abiraterone acetate to improve anti-androgen therapy for CR PCa.