作者
Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Yuhree Kim, Doris Wagner, Kazunari Sasaki, Andrea Beer, Christoph Schwarz, Inger Marie Løes, Maria Smolle, Carsten Kamphues, Jin He, Timothy M Pawlik, Klaus Kaczirek, George Poultsides, Per Eystein Lønning, John L Cameron, Richard A Burkhart, Armin Gerger, Federico N Aucejo, Martin E Kreis, Christopher L Wolfgang, Matthew J Weiss
发表日期
2018/7/1
期刊
JAMA surgery
卷号
153
期号
7
页码范围
e180996-e180996
出版商
American Medical Association
简介
Importance
BRAFmutations are reportedly associated with aggressive tumor biology. However, in contrast with primary colorectal cancer, the association of V600E and non-V600EBRAFmutations with survival and recurrence after resection of colorectal liver metastases (CRLM) has not been well studied.
Objective
To investigate the prognostic association ofBRAFmutations with survival and recurrence independently and compared with other prognostic determinants, such asKRASmutations.
Design, Setting, and Participants
In this cohort study, all patients who underwent resection for CRLM with curative intent from January 1, 2000, through December 31, 2016, at the institutions participating in the International Genetic Consortium for Colorectal Liver Metastasis and had data onBRAFandKRASmutational status were retrospectively identified. Multivariate Cox proportional hazards regression models were used to assess …
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GA Margonis, S Buettner, N Andreatos, Y Kim… - JAMA surgery, 2018