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Avian tibial dyschondroplasia disease is common in fast growing chickens round the world in which growth plate/cartilage accumulates in metaphyseal region of tibial bone, which is similar to mammalian osteochondrosis (Orth and Cook, 1994). TD is characterized by avascular and non-mineralize cartilage in the tibial growth plate (Tian et al., 2013). The TD is described as abnormal differentiation of GP chondrocytes, those normally lead to cartilage vascularization, mineralization and bone formation (Pines et al., 1998; Shahzad et al., 2014a).