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The key objective of poultry husbandry is to provide safe and nutritious food for the growing population. The technique of delivering various nutrients, nutraceuticals, vaccines, immunostimulants, phytochemicals and medicinal herbs via the in ovo route is gaining wide attention among scientists worldwide for improving poultry productivity, boosting immune response and safeguarding the health. Embryonic growth in poultry has been manipulated through direct administration of biological compounds into embryonated eggs during the mid and late phase of incubation. This shows potential to enhance hatchability, superior nutritional status, higher chick quality, improve post-hatch performance and ultimately reduce the challenges associated with infections and oxidative stress, as well as minimize the use of synthetic antibiotic growth promoters in poultry production. In the last two decades, several studies have …