作者
Marie A Bogoyevitch, Kevin RW Ngoei, Teresa T Zhao, Yvonne YC Yeap, Dominic CH Ng
发表日期
2010/3/1
来源
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics
卷号
1804
期号
3
页码范围
463-475
出版商
Elsevier
简介
c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening strategies following studies that have shown their critical roles in the development of a number of diseases, such as diabetes, neurodegeneration and liver disease. We discuss recent advances in the discovery and development of ATP-competitive and ATP-noncompetitive JNK inhibitors. Because understanding the modes of actions of these inhibitors and improving their properties will rely on a better understanding of JNK structure, JNK catalytic mechanisms and substrates, recent advances in these areas of JNK biochemistry are also considered. In addition, the use of JNK gene knockout animals is continuing to reveal in vivo functions for these kinases, with tissue-specific roles now being dissected with tissue-specific knockouts. These …
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MA Bogoyevitch, KRW Ngoei, TT Zhao, YYC Yeap… - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2010