作者
Tonay Inceboz, Fatma Yurt Lambrecht, Erdem Surucu, Osman Yilmaz, Altug Yavasoglu, Kubra Durkan, Başak Baykara, Recep Bekis, Ahmet Uner
发表日期
2013/2/1
期刊
Journal of drug targeting
卷号
21
期号
2
页码范围
175-179
出版商
Taylor & Francis
简介
We aimed to assess the ability of 131I-Pyrimethamine scintigraphy to detect the lesions of Toxoplasma gondii infection. An experimental model of toxoplasmosis was developed. The presence of toxoplasmosis was confirmed 60 days after implantation. Pyrimethamine was radioiodinated with I-131. The radioligand was validated by the requisite quality control tests to check its radiolabeling efficiency, in vitro stability and radiochemical purity etc. 131I-Pyrimethamine (specific activity: 7.08 MBq/µmol) was injected intravenously into the tail vein of the control and infected rats. Static whole body images of the rats were acquired under the gamma camera at 5 min, 45 min, 2 h, 6 h, and 24 h following the intravenous administration of the radioactivity (3.7 MBq/rat). Then the scintigraphic data were analyzed both visually and semiquantitatively. Regions of interest (ROIs) were drawn over the organs (thyroid, stomach …
学术搜索中的文章
T Inceboz, F Yurt Lambrecht, E Surucu, O Yilmaz… - Journal of drug targeting, 2013