作者
Emma Pritchard, Philippa C Matthews, Nicole Stoesser, David W Eyre, Owen Gethings, Karina-Doris Vihta, Joel Jones, Thomas House, Harper VanSteenHouse, Iain Bell, John I Bell, John N Newton, Jeremy Farrar, Ian Diamond, Emma Rourke, Ruth Studley, Derrick Crook, Tim EA Peto, A Sarah Walker, Koen B Pouwels
发表日期
2021/8
期刊
Nature medicine
卷号
27
期号
8
页码范围
1370-1378
出版商
Nature Publishing Group US
简介
The effectiveness of COVID-19 vaccination in preventing new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the general community is still unclear. Here, we used the Office for National Statistics COVID-19 Infection Survey—a large community-based survey of individuals living in randomly selected private households across the United Kingdom—to assess the effectiveness of the BNT162b2 (Pfizer–BioNTech) and ChAdOx1 nCoV-19 (Oxford–AstraZeneca; ChAdOx1) vaccines against any new SARS-CoV-2 PCR-positive tests, split according to self-reported symptoms, cycle threshold value (<30 versus ≥30; as a surrogate for viral load) and gene positivity pattern (compatible with B.1.1.7 or not). Using 1,945,071 real-time PCR results from nose and throat swabs taken from 383,812 participants between 1 December 2020 and 8 May 2021, we found that vaccination with the ChAdOx1 or …
学术搜索中的文章
E Pritchard, PC Matthews, N Stoesser, DW Eyre… - Nature medicine, 2021