作者
Mark Ainsworth, Monique Andersson, Kathryn Auckland, J Kenneth Baillie, Eleanor Barnes, Sally Beer, Amy Beveridge, Sagida Bibi, Luke Blackwell, Martyna Borak, Abbie Bown, Tim Brooks, Nicola A Burgess-Brown, Susana Camara, Matthew Catton, Kevin K Chau, Thomas Christott, Elizabeth Clutterbuck, Jesse Coker, Richard J Cornall, Stuart Cox, David Crawford-Jones, Derrick W Crook, Silvia D'Arcangelo, Wanwisa Dejnirattsai, Julie MM Dequaire, Stavros Dimitriadis, Kate E Dingle, George Doherty, Christina Dold, Tao Dong, Susanna J Dunachie, Daniel Ebner, Marc Emmenegger, Alexis Espinosa, David W Eyre, Rory Fairhead, Shayan Fassih, Conor Feehily, Sally Felle, Alejandra Fernandez-Cid, Maria Fernandez Mendoza, Thomas H Foord, Thomas Fordwoh, Deborah Fox McKee, John Frater, Veronica Gallardo Sanchez, Nick Gent, Dominique Georgiou, Christopher J Groves, Bassam Hallis, Peter M Hammond, Stephanie B Hatch, Heli J Harvala, Jennifer Hill, Sarah J Hoosdally, Bryn Horsington, Alison Howarth, Tim James, Katie Jeffery, Elizabeth Jones, Anita Justice, Fredrik Karpe, James Kavanagh, David S Kim, Richard Kirton, Paul Klenerman, Julian C Knight, Leonidas Koukouflis, Andrew Kwok, Ullrich Leuschner, Robert Levin, Aline Linder, Teresa Lockett, Sheila F Lumley, Spyridoula Marinou, Brian D Marsden, Jose Martinez, Lucas Martins Ferreira, Lara Mason, Philippa C Matthews, Alexander J Mentzer, Alexander Mobbs, Juthathip Mongkolsapaya, Jordan Morrow, Shubhashish MM Mukhopadhyay, Matthew J Neville, Sarah Oakley, Marta Oliveira, Ashley Otter, Kevin Paddon, Jordan Pascoe, Yanchun Peng, Elena Perez, Prem K Perumal, Timothy EA Peto, Hayleah Pickford, Rutger J Ploeg, Andrew J Pollard, Anastasia Richardson, Thomas G Ritter, David J Roberts, Gillian Rodger, Christine S Rollier, Cathy Rowe, Justine K Rudkin, Gavin Screaton, Malcolm G Semple, Alex Sienkiewicz, Laura Silva-Reyes, Donal T Skelly, Alberto Sobrino Diaz, Lizzie Stafford, Lisa Stockdale, Nicole Stoesser, Teresa Street, David I Stuart, Angela Sweed, Adan Taylor, Hannah Thraves, Hoi P Tsang, Marije K Verheul, Richard Vipond, Timothy M Walker, Susan Wareing, Yolanda Warren, Charlie Wells, Clare Wilson, Kate Withycombe, Rebecca K Young
发表日期
2020/12/1
期刊
The Lancet Infectious Diseases
卷号
20
期号
12
页码范围
1390-1400
出版商
Elsevier
简介
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in 2020. Testing is crucial for mitigating public health and economic effects. Serology is considered key to population-level surveillance and potentially individual-level risk assessment. However, immunoassay performance has not been compared on large, identical sample sets. We aimed to investigate the performance of four high-throughput commercial SARS-CoV-2 antibody immunoassays and a novel 384-well ELISA.
Methods
We did a head-to-head assessment of SARS-CoV-2 IgG assay (Abbott, Chicago, IL, USA), LIAISON SARS-CoV-2 S1/S2 IgG assay (DiaSorin, Saluggia, Italy), Elecsys Anti-SARS-CoV-2 assay (Roche, Basel, Switzerland), SARS-CoV-2 Total assay (Siemens, Munich, Germany), and a novel 384-well ELISA (the Oxford immunoassay). We derived sensitivity and specificity from 976 …
学术搜索中的文章
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
M Ainsworth, M Andersson, K Auckland, JK Baillie… - The Lancet Infectious Diseases, 2020