作者
Ngo Truong Giang, Hoang Van Tong, Trinh Huu Nghia, Hoang Vu Hung, Can Van Mao, Nguyen Truong Giang, Ho Anh Son, Thirumalaisamy P Velavan, Quyet Do, Nguyen Linh Toan
发表日期
2020/6/1
期刊
International Journal of Infectious Diseases
卷号
95
页码范围
253-261
出版商
Elsevier
简介
Background and objective
The human ficolin-2, encoded by FCN2, recognizes pathogen-associated acetylated residues on their cell surfaces and activates the lectin complement cascade. This study aimed to investigate the contribution of human ficolin-2 and the functional FCN2 genetic variants in dengue virus (DENV) infection and in clinical progression.
Methods
FCN2 genetic polymorphisms in the promoter, intron 7 and exon 8 were genotyped in 279 patients with dengue fever and in 200 healthy controls by direct Sanger sequencing. The ficolin-2 levels were measured in serum samples by ELISA and correlated with clinical data.
Results
The frequencies of +6031GG, +6220GG and +6424TT genotypes were significantly higher in dengue patients compared to healthy controls indicating an increased risk of dengue fever. The SNPs rs11103563 (+6031A/G), rs7872508 (+6220 T/G), and rs7851696 (+6424G/T …
学术搜索中的文章
NT Giang, H Van Tong, TH Nghia, HV Hung… - International Journal of Infectious Diseases, 2020