作者
J Matthew Reinersman, Melissa L Johnson, Gregory J Riely, Dhananjay A Chitale, Anthony D Nicastri, Gerald A Soff, Ann G Schwartz, Camelia S Sima, Getinet Ayalew, Christopher Lau, Maureen F Zakowski, Valerie W Rusch, Marc Ladanyi, Mark G Kris
发表日期
2011/1/1
期刊
Journal of Thoracic Oncology
卷号
6
期号
1
页码范围
28-31
出版商
Elsevier
简介
Introduction
The detection of mutations in the epidermal growth factor receptor (EGFR) gene, which predict sensitivity to treatment with EGFR tyrosine kinase inhibitors, represents a major advance in the treatment of lung adenocarcinoma. KRAS mutations confer resistance to EGFR-tyrosine kinase inhibitors. The prevalence of these mutations in African American patients has not been thoroughly investigated.
Methods
We collected formalin-fixed, paraffin-embedded material from resected lung adenocarcinomas from African American patients at three institutions for DNA extraction. The frequencies of EGFR exon 19 deletions, exon 21 L858R substitutions, and KRAS mutations in tumor specimens from African American patients were compared with data in white patients (n = 476).
Results
EGFR mutations were detected in 23 of the 121 specimens from African American patients (19%, 95% confidence interval [CI]: 13 …
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