作者
Arunava Ghosh, Raymond C Coakley, Teresa Mascenik, Temperance R Rowell, Eric S Davis, Keith Rogers, Megan J Webster, Hong Dang, Laura E Herring, M Flori Sassano, Alessandra Livraghi-Butrico, Scott K Van Buren, Lee M Graves, Melissa A Herman, Scott H Randell, Neil E Alexis, Robert Tarran
发表日期
2018/7/1
期刊
American journal of respiratory and critical care medicine
卷号
198
期号
1
页码范围
67-76
出版商
American Thoracic Society
简介
Rationale: E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown.
Objectives: To determine the effects of chronic vaping on pulmonary epithelia.
Methods: We performed research bronchoscopies on healthy nonsmokers, cigarette smokers, and e-cigarette users (vapers) and obtained bronchial brush biopsies and lavage samples from these subjects for proteomic investigation. We further employed in vitro and murine exposure models to support our human findings.
Measurements and Main Results: Visual inspection by bronchoscopy revealed that vaper airways appeared friable and erythematous. Epithelial cells from biopsy samples revealed approximately 300 proteins that were differentially expressed in smoker and vaper airways, with only 78 proteins being commonly altered in both …
学术搜索中的文章
A Ghosh, RC Coakley, T Mascenik, TR Rowell… - American journal of respiratory and critical care …, 2018